TRICYCLIC COMPOUNDS USEFUL AS ANGIOTENSIN II AGONISTS
摘要
There is provided compounds of formula (I), wherein R<sp>1</sp>, X<sb>1</sb>, X<sb>2</sb>, X<sb>3</sb>, X<sb>4</sb>, Y<sb>1</sb>, Y<sb>2</sb>, Y<sb>3</sb>, Y<sb>4</sb>, Z<sb>1</sb>, Z<sb>2</sb>, R<sp>2</sp> and R<sp>3</sp> have meanings given in the description, and pharmaceutically−acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of <i>inter alia</i> gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.