发明名称 |
RESPONSIVE MICROGEL AND METHODS RELATED THERETO |
摘要 |
A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of 'dangling chains' and wherein the 'dangling chains' of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substanially linear and sustained release of the therapeutic entity under physiological conditions.
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申请公布号 |
WO03063909(A1) |
申请公布日期 |
2003.08.07 |
申请号 |
WO2002IB05785 |
申请日期 |
2002.12.31 |
申请人 |
SUPRATEK PHARMA INC. |
发明人 |
BROMBERG, LEV, E.;TEMCHENKO, MARINA |
分类号 |
A61K47/32;A61K8/02;A61K8/90;A61K9/00;A61K9/16;A61K9/22;A61K47/34;A61Q19/00;(IPC1-7):A61K47/32 |
主分类号 |
A61K47/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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