PROCESS FOR THE PREPARATION OF HIGH PURITY PERINDOPRIL AND INTERMEDIATES USEFUL IN THE SYNTHESIS

摘要

The invention relates to 1-{2S-[1S-ethoxycarbonylbutylamino]propionyl}-3aS,7aSoctahydroindol-2S-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I' thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the preparation thereof. The invention also relates to new intermediates of the general Formula III wherein R stands for lower alkyl or aryl lower alkyl. The compound of the Formula I - perindopril - is a known ACE inhibitor.