发明名称 |
Nucleophile-stable thioester generating compounds, methods of production and use |
摘要 |
The invention is directed to nucleophile-stable thioester generating compounds comprising an orthothioloester or a carboxyester thiol, methods of production and use. The compounds and methods have wide applicability in organic synthesis, including the generation of peptide-, polypeptide- and other polymer-thioesters. The invention is particularly useful for generating activated-thioesters from precursors that are made under conditions in which strong nucleophiles are employed, such as peptides or polypeptides made using Fmoc SPPS, as well as multi-step ligation or conjugation schemes that require (or benefit from the use of) compatible selective approaches for directing a specific ligation or conjugation reaction of interest.
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申请公布号 |
US2003149234(A1) |
申请公布日期 |
2003.08.07 |
申请号 |
US20030332454 |
申请日期 |
2003.01.09 |
申请人 |
BOTTI PAOLO;BRADBURNE JAMES A.;KENT STEPHEN B.H. |
发明人 |
BOTTI PAOLO;BRADBURNE JAMES A.;KENT STEPHEN B.H. |
分类号 |
C07D317/32;C07C323/52;C07C323/59;C07D317/34;C07D319/06;C07K1/00;C07K1/02;C07K1/04;C07K7/00;(IPC1-7):C07K7/00;C07C327/02 |
主分类号 |
C07D317/32 |
代理机构 |
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地址 |
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