Transfektionskompetente Moleküle

摘要

The invention relates to conjugates of lipids and basic, membrane disturbing peptides, particularly compounds of the formula (R-CONH)n-R3(I) and (R-S-S)n-R3(II) wherein R is the hydrocarbyl moiety of a straight-chain or branched-chain, saturated or unsaturated aliphatic carboxylic acid, or a phospholipid moiety having a free valence bond; R3 is a basic membrane disturbing peptide having a free valence bond at one or two carbon atom(s); and n is 1 or 2. These conjugates can be used as a vector for transfecting a cell with a polynucleotide or any other anionic macromolecule.