POLYMORPHISMS IN ELASTIN, FIBRILLIN, AND RELATED GENES AS PREDISPOSING TO RESTENOSIS AND TO ATHEROSCLEROSIS

摘要

Methods are provided for assessing the risk of developing restenosis in an individual, by detecting the presence of biologically important polymorphisms in genes involved in the formation of the elastin fiber network. In particular, detection of polymorphorphisms in the elastin, fibrillin, fibrillin−1, fibrillin−2, lysyl oxidase, microfibril−associated glycoprotein, biglycan, osteopontin, and/or decorin genes allows the rapid and objective prediction of the risk of developing restenosis. Methods for treating restenosis and for reducing its recurrence also are provided.