发明名称 |
Nanoparticle delivery vehicle |
摘要 |
A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.
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申请公布号 |
US2003147966(A1) |
申请公布日期 |
2003.08.07 |
申请号 |
US20020192393 |
申请日期 |
2002.07.10 |
申请人 |
FRANZEN STEFAN;FELDHEIM DANIEL L.;TKACHENKO ALEXANDER G.;GODEK MARISHA L.;RYAN JOSEPH A.;ANDERSON MILES F.;FRANZEN STEFAN |
发明人 |
FRANZEN STEFAN;FELDHEIM DANIEL L.;TKACHENKO ALEXANDER G.;GODEK MARISHA L.;RYAN JOSEPH A.;ANDERSON MILES F.;FRANZEN STEFAN |
分类号 |
A61K9/14;A61K9/51;A61K31/7088;A61K38/00;A61K45/00;A61K45/06;A61K47/02;A61K47/04;A61K47/16;A61K47/18;A61K47/30;A61K47/32;A61K47/34;A61K47/36;A61K47/42;A61K47/48;A61K48/00;A61K49/00;A61P43/00;C12N15/88;(IPC1-7):A61K48/00;C12N15/85;A61K9/16;A61K9/50 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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地址 |
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