摘要 |
It is intended to provide compounds represented by the following general formula (I) which have a high affinity for human thyroid hormone receptors, in particular, human thyroid hormone receptor beta, medicinal compositions containing the same, and use thereof: (I) wherein W represents O, S(O)m, CH2, etc.; R1 represents halogeno, lower alkyl, halo(lower alkyl), CN, etc.; R2 represents hydrogen, halogeno, lower alkyl, etc.; R3 represents hydroxy, etc.; R4 represents hydrogen, halogeno, alkyl, halo(lower alkyl), substituted alkyl, aryl, aralkyl, alkoxy, substituted alkoxy, alkanoyl, aroyl, -CONR7(R8), -S(O)mR9, -SO2NR7(R8), etc.; R5 represents hydrogen, halogeno, alkyl, substituted alkyl, etc.; and A represents -N(R6)CO-A1-COR10, etc.
|
申请人 |
KISSEI PHARMACEUTICAL CO., LTD.;SHIOHARA, HIROAKI;NAKAMURA, TETSUYA;KIKUCHI, NORIHIKO;OZAWA, TOMONAGA;KITAZAWA, MAKIO |
发明人 |
SHIOHARA, HIROAKI;NAKAMURA, TETSUYA;KIKUCHI, NORIHIKO;OZAWA, TOMONAGA;KITAZAWA, MAKIO |