摘要 |
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease. |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
KUCHROO, VIJAY, K.;MONNEY, LAURENT;GREEFIELD, EDWARD, A.;GAGLIA, JASON, L.;FREEMAN, GORDON, J.;WALDNER, HANSPETER |