| 摘要 |
<p>The DegP protease is essential for clearance of denatured or aggregated proteins from the periplasmic space in bacteria. The present invention relates to novel methods for treatment and/or prophylaxis of diseases caused by pilus-forming bacteria by modulating DegP protease activity. Also disclosed is the identification of DegP cleavage sites on PapA pilin subunit and methods for identifying substances which modulate DegP activity. The present invention further provides for polypeptides identified which are cleavable substrates for DegP. The present invention provides for the identification of a polypeptide which enhances DegP protease activity. The current invention facilitates the development of a novel class of anti-infectives targeting DegP protease.</p> |
