INDIRECT MEASUREMENT OF TISSUE ANALYTES THROUGH TISSUE PROPERTIES

摘要

Methods and system for noninvasive determination of tissue analytes through NIR spectroscopy utilize optical properties of tissue as reflected in key spectroscopic measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured analytical signal of skin, leading to a biased non-invasive analyte measurement. Changes (106) in the optical properties of tissue are detected by identifying key features responsive to physiological variations. Conditions (107) not conducive to the non-invasive measurement detected. Non-invasive measurements that are biased by physiological changes in tissue are compensated (103). In an alternate embodiment, the analyte is measured indirectly based on natural physiological response of tissue to analyte concentration. A spectroscopic device capable of such measurements is provided.