发明名称 |
PROCESS FOR FORMULATION OF ANTIBIOTIC COMPOUNDS |
摘要 |
A novel process for preparing a stabilized, lyophilized carbapenem, antibiotic formulation suitable for intravenous administration to patients in need thereof, wherein the active ingredient is of formula II:The process entails compounding a unstable, monosodium salt carbapenem with a sodium bicarbonate solution at a temperature range of from about 0° to about 5° C. while maintaining a pH between about 7.0 and about 8.0, filtering the resultant solution, bottling under sterile conditions, and lyophilizing to produce the formulation. |
申请公布号 |
EP1332145(A1) |
申请公布日期 |
2003.08.06 |
申请号 |
EP20010934937 |
申请日期 |
2001.04.27 |
申请人 |
MERCK & CO., INC. |
发明人 |
AL-DEHNEH, ANTHONY;HUNKE, WILLIAM, A.;ILLIG, KATHLEEN, J.;KANIKE, ANAND;PATEL, HIREN;REYNOLDS, SCOTT, D.;TSINONTIDES, STELIOS, C. |
分类号 |
A61J3/00;A61K9/19;A61K31/40;A61K31/407;A61K47/04;A61P31/04;C07D477/00;C07D477/02;C07D477/20 |
主分类号 |
A61J3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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