Immunogens, antibodies and conjugates to ketamine and its metabolites

摘要

The present invention discloses haptens derivatised with a crosslinker at the N-position of norketaminc or at an O- position of a hydroxynorketamine or of a hydroxyketamine. The invention also provides immunogens comprising such haptens, coupled to an antigenicity-conferring carrier material, as well as, antibodies raised against such haptens. In addition, the invention concerns conjugates comprising such haptens, covalently bonded to a detectable labelling agent. The invention also provides methods and kits for detecting or determining ketamine and its primary metabolite, norketamine, using conjugates and antibodies of the present invention.