| 发明名称 |
Synthesis of epothilones, intermediates thereto and analogues thereof |
| 摘要 |
The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.
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| 申请公布号 |
US6603023(B2) |
申请公布日期 |
2003.08.05 |
| 申请号 |
US20020062376 |
申请日期 |
2002.02.01 |
| 申请人 |
SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
DANISHEFSKY SAMUEL J.;BERTINATO PETER;SU DAI-SHI;MENG DONGFANG;CHOU TING-CHAO;KAMENECKA TED;SORENSEN ERIK J.;BALOG AARON;SAVIN KENNETH A.;KUDUK SCOTT;HARRIS CHRISTINA;ZHANG XIU-GUO;BERTINO JOSEPH R. |
| 分类号 |
A61K31/335;A61K31/337;A61K31/425;A61K31/475;A61K31/70;A61K45/06;C07C59/76;C07C69/007;C07C69/738;C07D277/22;C07D277/24;C07D313/00;C07D413/06;C07D417/06;C07D417/14;C07D493/04;C07F7/18;(IPC1-7):C07D313/00;C07D407/02;C07D493/02 |
主分类号 |
A61K31/335 |
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