Quinoxalinediones, process and intermediates for their production, their use and pharmaceutical compositions based on them

摘要

The invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein R is a 5-membered ring heteroaryl group containing 3 or 4 nitrogen heteroatoms which is linked to the quinoxalinedione ring by a ring carbon or nitrogen atom, or is a 6-membered ring heteroaryl group containing from 1 to 3 nitrogen heteroatoms which is linked to the quinoxalinedione ring by a ring carbon atom, either of said groups being optionally benzo-fused and optionally substituted, including in the benzo-fused portion, by 1 or 2 substituents; R1 and R2 are each independently selected from H, fluoro, chloro, bromo, C1-C4 alkyl and halo(C1-C4)alkyl; and their pharmaceutically suitable salts; process and intermediates for production of these quinoxalinediones, pharmaceutical compositions based on these compounds and their use.