3-Substituted 1-arylindole compounds, pharmaceutical compositions containing them and their use

摘要

3-Substituted 1-arylindole compound having general formula (I) wherein Ar is an optionally substituted aryl group; X represents a bond, a divalent hydrocarbon group or methyleneoxy or -thioxo; R1-R2 are hydrogen or substituents; R5 is hydrogen, hydroxy, alkoxy, halogen, trifluoromethyl, alkyl or alkenyl; R6 and R7 are hydrogen, alkyl or alkenyl; R8 is alkyl or alkenyl or represents a group of formula (1a) or (1b); wherein: W is O or S; U is N or CH; Z is (CH2)m, 1,2-phenylene, CH=CH, COCH2 or CSCH2-; V is O, S, CH2, or NR10, wherein R10 is hydrogen or alkyl; U1 is O, S, CH2 or NR11, wherein R11 is as R10; and V1 is NR12R13, OR14, SR15 or CR16R17R18, where each of R12-R18 are as the R10-substituents; R9 is hydrogen or alkyl; or R9 is linked to R7 to form a ring; or R8 and R9 together form a morpholinyl or piperidinyl ring, the latter optionally substituted by alkyl or a group of formula (1a) or (1b), or a carbamoyl group, show central antiserotonergic activity and possibly also antidopaminergic activity and are, accordingly, useful in the treatment of central nervous system (CNS) disorders. The compounds are prepared by methods known per se.