EX-VIVO GENE THERAPY OF DIABETES USING IAP POLYPEPTIDES

摘要

The invention features methods for the treatment of diabetes by administering a IAP nucleic acid sequence to a subject. One methodincludes the steps of. (a) providing one or more insulin-producing cells or one or more precursor cells capable of producing progeny cells tha tproduce insulin; (b) transducing the cells with a nucleic acid sequence encoding an IAP plypeptide, the nucleic acid sequence postioned for expression of the IAP polypeptide in the cells, wherein expression of the IAP polypeptide increases survival of the cells relative to untreated control cells; and (c)transplanting the cells from step (b) that have been transduced with anucleic acid sequence encoding an IAP polypeptide into the individual, wherein the cells produce insulin in amounts sufficient to treat diabetes in the individual.