发明名称 |
Use of HMGB fragments as anti-inflammatory agents |
摘要 |
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
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申请公布号 |
US2003144201(A1) |
申请公布日期 |
2003.07.31 |
申请号 |
US20020300072 |
申请日期 |
2002.11.20 |
申请人 |
NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE |
发明人 |
TRACEY KEVIN J.;YANG HUAN;WARREN HOWLAND SHAW;FINK MITCHELL P. |
分类号 |
A61K38/00;C07K14/47;(IPC1-7):A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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