| 摘要 |
<p>A method of identifying chemotherapeutic activity in a compound other than etoposide, or combination of compounds, comprises: i) treating a cell in which an anti-apoptotic protein is over-expressed with the compound, or combination of compounds, to be assessed for chemotherapeutic activity; and ii) assaying for a change in the conformation of Bak expressed in the cell. The presence of a change in the conformation of Bak indicates that the compound, or combination of compounds, has chemotherapeutic activity, and the absence of a change in the conformation of Bak indicates that the compound, or combination of compounds, does not have chemotherapeutic activity.</p> |
