发明名称 |
INTEGRIN TARGETED IMAGING AGENTS |
摘要 |
Emulsions preferably of nanopartides formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for QvP3 integrin, other th an an antibody. The nanoparticles may further include biologically active agent s, radionuclides, or other imaging agents.
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申请公布号 |
CA2474386(A1) |
申请公布日期 |
2003.07.31 |
申请号 |
CA20032474386 |
申请日期 |
2003.01.24 |
申请人 |
BARNES-JEWISH HOSPITAL;BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC. |
发明人 |
WICKLINE, SAMUEL A.;HARRIS, TOM;LANZA, GREGORY |
分类号 |
A61K47/22;A61K47/42;A61K47/48;A61K49/00;A61K49/18;(IPC1-7):C07D471/04;C07D401/04;C07D215/233 |
主分类号 |
A61K47/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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