发明名称 INTEGRIN TARGETED IMAGING AGENTS
摘要 Emulsions preferably of nanopartides formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for QvP3 integrin, other th an an antibody. The nanoparticles may further include biologically active agent s, radionuclides, or other imaging agents.
申请公布号 CA2474386(A1) 申请公布日期 2003.07.31
申请号 CA20032474386 申请日期 2003.01.24
申请人 BARNES-JEWISH HOSPITAL;BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC. 发明人 WICKLINE, SAMUEL A.;HARRIS, TOM;LANZA, GREGORY
分类号 A61K47/22;A61K47/42;A61K47/48;A61K49/00;A61K49/18;(IPC1-7):C07D471/04;C07D401/04;C07D215/233 主分类号 A61K47/22
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