PREDICTION OF FUNCTIONAL AND STRUCTURAL PROPERTIES OF POLYPEPTIDES
摘要
The invention provides a method for identifying a polypeptide that binds a ligand. The method includes the steps of (a) comparing a sequence of a polypeptide to a sequence model for polypeptides that bind a ligand, wherein the sequence model comprises representations of amino acids consisting of a subset of amino acids, the subset of amino acids having one or more atom within a selected distance from a bound ligand in the polypeptides that bind the ligand; and (b) determining a relationship between the sequence and the sequence model, wherein a correspondence between the sequence and the sequence model identifies the polypeptide as a polypeptide that binds the ligand.
申请公布号
WO02059715(A3)
申请公布日期
2003.07.31
申请号
WO2001US50756
申请日期
2001.12.28
申请人
TRIAD THERAPEUTICS, INC.;SEM, DANIEL, S.;BAKER, BRIAN;HANSEN, MARK, R.