| 摘要 |
The invention provides novel human polynucleotides unique to, associated with, or highly expressed activated T-lymphocytes (Regulated in Activated T Lymphocytes). The novel polynucleotides were derived from a cDNA subtraction library constructed from human peripheral blood T lymphocytes activated with antibodies against CD3 and CD28 cell surface antigens. The invention also provides for the use and production of the polynucleotides, antisense polynucleotides, amino acid sequences, and/or polypeptides, peptides, and antigenic epitopes thereof encoded by these polynucleotides, and to compositions and methods comprising the polynucleotides and polypeptides and peptides identified herein for modulation of an immune response and for the diagnosis, prevention, or treatment of disorders associated with aberrant cellular development and differentiation including cancer and inflammation, graft vs. host disease, transplantation rejection and autoimmune disease.
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