| 摘要 |
<p>The present invention relates to methods for the synthesis and isolation of the protegrin IB 367; as well as analogs and derivatives thereof. The present method utilizes both solid phase and liquid phase peptide synthesis procedures to synthesize and combine specific peptide fragment intermediates. This invention relates to processes comprising solid phase peptide synthesis procedures in which glycine is the amino acid attached to the solid support, and both solid and liquid phase synthesis methods that use side-chain-unprotected arginine residues.</p> |
