2-THIA-1,6,8-TRIAZA-NAPHTALENE-2,2-DIOXIDES AS CDK INHIBITORS

摘要

The present invention provides 2−thia−1 ,6,8−triaza−naphthalene−2,2− dioxide inhibitors of cyclin−dependent kinases, uses thereof and pharmaceutical compositions thereof. These compounds are useful for treating cell proliferative disorders, such as cancer, atherosclerosis, and restenosis. These compounds are potent inhibitors of kinases such as cyclin−dependent (cdks) and growth factor−mediated kinases. The present invention also provides a method of treating cell proliferative disorders formula (1).