6-FLUOROBICYCLO[3.1.0]HEXANE DERIVATIVES

摘要

Antidepressants containing as the active ingredient compounds having group II metabotropic glutamate receptor antagonism; and 2-amino-3-alkoxy-6- fluorobicyclo[3.1.0]- hexane-2,6-dicarboxylic acid derivatives represented by the general formula [I], pharmaceutically acceptable salts thereof, or hydrates of the salts: [I] wherein R1 and R2 may be the same or different from each other and are each hydroxyl, C1-10 alkoxy, or the like; R3 is C1-10 acyl, C1-6 alkoxy-C1-6 acyl, or the like; and R4 and R5 may be the same or different from each other and are each hydrogen, C1-10 alkyl, or the like.