PHOSPHINIC PSEUDO-PEPTIDE DERIVATIVES FOR SELECTIVE INHIBITION OF THE ACTIVE C-TERMINAL SITE OF ANGIOTENSIN CONVERTING ENZYME (I) (ACE)

摘要

The invention relates to the use of phosphinic pseudo-peptide derivatives for production of a medicament for the selective inhibition of the active C-terminal site of angiotensin converting enzyme (I). Said derivatives are of formula (II), where, R1 = optionally a normal protective group for amino functions in peptide chemistry or an amino acid or a peptide protected by the above type of protective group, R2 and R3 = a natural or synthetic amino acid side chain and R4 and R5 = a hydrogen atom or a counter-ion. The above finds application in the prevention and treatment of cardiovascular disease in humans.