发明名称 |
Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics |
摘要 |
The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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申请公布号 |
US2003143657(A1) |
申请公布日期 |
2003.07.31 |
申请号 |
US20010010227 |
申请日期 |
2001.12.06 |
申请人 |
HAMER LISBETH;ADACHI KIICHI;DEZWAAN TODD;LO SZE-CHUNG;MONTENEGRO-CHAMORRO MARIA VICTORIA;FRANK SHERYL;DARVEAUX BLAISE;MAHANTY SANJOY;HEINIGER RYAN;SKALCHUNES AMY;PAN HUAQIN;TARPEY REX;SHUSTER JEFFREY;TANZER MATTHEW M. |
发明人 |
HAMER LISBETH;ADACHI KIICHI;DEZWAAN TODD;LO SZE-CHUNG;MONTENEGRO-CHAMORRO MARIA VICTORIA;FRANK SHERYL;DARVEAUX BLAISE;MAHANTY SANJOY;HEINIGER RYAN;SKALCHUNES AMY;PAN HUAQIN;TARPEY REX;SHUSTER JEFFREY;TANZER MATTHEW M. |
分类号 |
C12N9/00;C12N9/10;C12N9/16;C12N9/88;C12Q1/18;(IPC1-7):C12Q1/32 |
主分类号 |
C12N9/00 |
代理机构 |
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