Emulsions preferably of nanopartides formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for QvP3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
申请公布号
WO03062198(A1)
申请公布日期
2003.07.31
申请号
WO2003US02380
申请日期
2003.01.24
申请人
BARNES JEWISH HOSPITAL;BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.