| 摘要 |
<p>The invention relates to a method of obtaining purified citalopram or the salts thereof. The inventive method consists in purifying citalopram using selective extractions of citalopram or the impurities of same with organic dissolvents and water under determined pH and temperature conditions. The crude citalopram can be obtained by means of a method consisting in reacting 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-bromoisobenzofuran with copper cyanide.</p> |
