发明名称 |
Recombinant alpha-I-induronidase, methods for producing and purifying the same ad methods for treating diseases caused by deficiencies thereof. |
摘要 |
The present invention provides a recombinant human ±-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human, ±-L-iduronidase enzyme as well as methods to treat certain genetic disorders including ±-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1). |
申请公布号 |
ZA200203619(B) |
申请公布日期 |
2003.07.30 |
申请号 |
ZA20020003619 |
申请日期 |
2002.05.07 |
申请人 |
BIOMARIN PHARMACEUTICAL, INC.;HARBOR-UCLA RESEARCH AND EDUCATION INSTITUTE |
发明人 |
MINMIN QIN;WAI-PAN CHAN;LIN CHEN;PAULA A FITZPATRICK;JOHN M HENSTRAND;DAN J WENDT;GARY N ZECHERLE;CHRISTOPHER M STARR;EMIL D KAKKIS;BECKY TANAMACHI |
分类号 |
C12N15/09;A61K9/08;A61K38/00;A61K38/43;A61K38/47;A61K47/02;A61K47/10;A61K48/00;A61P3/00;A61P19/00;A61P43/00;C12N9/24;C12N9/88 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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