发明名称 |
THIOLATION OF PEPTIDES FOR RADIONUCLIDE-BASED RADIODETECTION AND RADIOTHERAPY |
摘要 |
<p>A method of radiolabeling a peptide, e.g., somatostatin or an analogue thereof or vasoactive intestinal peptide, with a radioisotope of technetium or rhenium, comprises the steps of: (a) reacting the peptide with an acetyl-protected <u>t</u>-thiol-containing, amine-reactive bifunctional chelating agent; (b) deprotecting the acetyl-<u>t</u>-thiol group to generate a free <u>t</u>-thiol group; and either (c) admixing the peptide-<u>t</u>-thiol-containing conjugate with a stannous salt; and (d) reacting the mixture of step (c) with pertechnetate or perrhenate, or (c') adding reduced pertechnetate or perrhenate to said peptide-<u>t</u>-thiol-containing conjugate, thereby forming a radiolabeled peptide. Kits for effecting the radiolabeling method, and methods of tumor detection/imaging or therapy are provided.</p> |
申请公布号 |
EP0831936(B1) |
申请公布日期 |
2003.07.30 |
申请号 |
EP19960919062 |
申请日期 |
1996.06.07 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
GOVINDAN, SERENGULAM, V.;GRIFFITHS, GARY, L.;HANSEN, HANS, L. |
分类号 |
A61K51/00;A61K38/22;A61K38/31;A61K51/08;A61M36/14;A61P35/00;C07K1/13;C07K14/575;C07K14/655;(IPC1-7):A61K51/00 |
主分类号 |
A61K51/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|