Cystic fibrosis medicaments

摘要

A method of treating cystic fibrosis in a patient comprising:administering to said patient an effective amount of a type V cyclic nucleotide phosphodisterase inhibitor,wherein said inhibitor is a compound of formula (I): wherein A is a five- or six-membered ring containing one or more N atoms, X is a substituent of formula (II): wherein R1 represents C1-4 alkyl, andX is positioned at either or both of the 2-position and/or the 8-position in (I).