发明名称 |
Process for preparing optically active 3,3,3-trifluoromethyl-2-alkylpropionic acid derivatives |
摘要 |
The invention relates to a novel method for the preparation of optically active 3,3,3-trifluoromethyl-2-alkyl propionic acid derivatives of the general formulae (I) and (II), in which R is ethyl or methyl and X is OH or NH2, provided that if R is methyl X<> -OH. The method comprises the reaction of a racemic propionic acid amide of the general formula (III) either by means of microorganisms which are able to use the propionic acid amide in the form of the racemate or one of its optically active isomers as the only nitrogen source or by means of a polypeptide with amidohydrolase activity which is able to hydrolyze the propionic acid amide. The invention also relates to new optically active representatives of this category of compounds.
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申请公布号 |
US6599721(B2) |
申请公布日期 |
2003.07.29 |
申请号 |
US20010938333 |
申请日期 |
2001.08.23 |
申请人 |
LONZA AG |
发明人 |
NAUGHTON ANDREW;SHAW NICHOLAS |
分类号 |
C12P41/00;C07B61/00;C07C53/21;C07C59/115;C07C231/06;C07C235/06;C07C237/06;C12P7/52;C12P13/02;C12R1/01;(IPC1-7):C12P13/02;C12P7/40;C12P7/42 |
主分类号 |
C12P41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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