Method for making coated gabapentine or pregabaline particles

摘要

A process for manufacturing coated particles of ã-aminobutyric acid analogue, whose lactam content by weight relative to the weight of ã-aminobutyric acid analogue is less than 0.5%, wherein a coating solution comprising at least one polymer in at least one organic solvent is sprayed on to the particles of ã-aminobutyric acid analogue. The coated particles of ã-aminobutyric acid analogue are used in the manufacture of multiparticulate tablets for oral administration without the use of water, in which the tablet disintegrates in less than 60 seconds in the oral cavity. Also disclosed are fast dispersible multiparticulate tablets that form stable suspensions in small volumes of water.