| 摘要 |
An 4'-oxo-spiro[cyclopropane-1,6'-[2H]-indene] derivative or a pharmaceutically acceptable salt thereof has the formula I which is useful for treating cancer wherein: R1 is hydrogen, hydroxy, mercapto, amino, halo, carboxy, nitro, or -(CH2)n-(X)-(Y); n is 0 to 4; X is oxy, thio, -N(Ra)-, or absent; Y is cycloalkyl, aryl, heteroaryl, a saccharide, an optionally protected amino acid, , OH, carboxy, a peptide, or an optionally branched optionally substituted optionally saturated 1 to 15 membered carbon chain optionally comprising 1, 2, or 3 non-peroxide oxy, thio or -N(Ra) -; R2 is carboxy, alkanoyl, alkoxycarbonyl, haloalkyl, -C(=O)NRdRe, a saccharide, an amino acid, a peptide, or optionally substituted alkyl; R3 is hydrogen, alkyl, alkoxy, alkylthio, aryl, heteroaryl, aryloxy, or heteroaryloxy; R4 is hydrogen or alkyl; and R5 is hydroxy, alkoxy, or alkanoyloxy; or R4 and R5 taken together are ethylenedioxy; R6 is hydrogen, carboxy, alkanoyl, alkoxycarbonyl, haloalkyl, -C(=O)NRfRg, a saccharide, an amino acid, a peptide, or optionally substituted alkyl and Ra, Rd, Re, Rf and Rg are each defined in the specification.
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