| 摘要 |
<p>A closure device is designed for attachment on a neck portion (1) of a separate container (2), preferably of glass material, which holds a first substance. The closure device defines a passage (10) extending between opposite first and second openings (11, 13) of the closure device. A sealing means (30) is arranged to close off the first opening (11) and confine a second substance in the passage (10). A penetration means (33) is incorporated in the device and operable to penetrate the sealing means (30) such that fluid communication is established between the passage (10) and the container (2). In a method of mixing the first and second substances, a medical practitioner exposes the second opening (13) by removing a non-resealable cap (8), by introducing and engaging the end of a syringe directly in the second opening (13), and by operating the penetration means (33) to penetrate the sealing means (30). By operating the syringe, the practitioner can transfer the first and second substances to the syringe, and mix the same in the process, with minimum need for sterilization.</p> |
