| 摘要 |
A process for the preparation of a compound of formula (I), wherein; R2 and R3 are independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, and phenyl, R6, R7 and R8 are independently selected from hydrogen, C1-6alkyl, fluoro, chloro, bromo, iodo, and -CF3, R11, R12 and R13 are independently selected from hydrogen, C1-6alkyl, fluoro, chloro, bromo, iodo, and -CF3, and Z is C1-4alkyl, The process comprises; (i) reacting a compound of formula (II), wherein R2, R3, R6, R7, R8, R11, R12, R13 and Z are as defined for formula (I), with a compound of formula (III), wherein LG is a leaving group selected from halogen, or alkyl- or arylsulfonate group, in an organic solvent and in the presence of a base, and (ii) collecting the resultant crystalline compound of formula (I).
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