| 摘要 |
An amidocarboxylic acid derivative of formula (I); where: R1 is H, alkyl or arylalkyl; R2 is alkylene; R3 is H, alkyl, alkoxy, alkylthio, halogen, nitro, dialkylamino, optionally substituted aryl, optionally substituted arylalkyl, hydroxyl or aliphatic acyl; R4 is H or alkyl; Z is alkylene; W is i) alkyl, ii) hydroxyl, iii) alkoxy, iv) alkylthio, v) optionally substituted aryl, vi) aryloxy that is optionally substituted on the aryl, vii) arylthio that is optionally substituted on the aryl, viii) aralkyl that is optionally substituted on the aryl, ix) aralkyloxy that is optionally substituted on the aryl, x) aralkylthio that is optionally substituted on the aryl, xi) aryloxyalkyl that is optionally substituted on the aryl, xii) monocyclic or dicyclic heteroaryl, xiii) monocyclic or dicyclic heteroaryloxy, xiv) monocyclic or dicyclic heteroarylthio, xv) monocyclic or dicyclic saturated heterocyclic, xvi) amino, xvii) monoalkylamino, xviii) dialkylamino, xix) N-alkyl-N-aryl-amino that is optionally substituted on the aryl, xx) arylamino that is optionally substituted on the aryl, xxi) arylalkylamino that is optionally substituted on the aryl or xxii) aralkyloxycarbonylamino that is optionally substituted on the aryl; X is optionally substituted aryl, optionally substituted monocyclic or dicyclic heteroaryl, when W is any of the groups i)-xv) as defined above; or X is optionally substituted aryl when W is any of the groups xvi) to xxii) as defined above; Y is a single bond, O, S or >N-R5. Also described are pharmaceutical compositions comprising the compound of formula (I). The compounds of formula (I) are useful for: lowering blood glucose, ameliorating insulin resistance, the prevention or therapy of diabetes mellitus, the prevention or therapy of impaired glucose tolerance, the prevention or therapy of insulin-resistant non-IGT, the prevention or therapy of diabetic complications and the prevention or therapy of gestational diabetes mellitus.
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