| 摘要 |
<p>The present invention relates to a compound of the general formula(I)wherein: R1 is a selected from the group consisting of (C1-C6)alkoxy(C1-C6)alkyl which may be substituted by a (C1-C6)alkoxy, phenyl-(C1-C6)-alkyl and phenyloxy-(C1-C6)-alkyl wherein the phenylgroup may be substituted with (C1-C6)alkyl, (C1-C6)alkoxy or halogen, and naphtyl-(C1-C6)-alkyl,R2 and R3 are both independently hydrogen or halogen,R4 is a biolabile ester forming group,as a pharmaceutically acceptable metal salt, characterized in that the salt is selected from the group consisting of the lithium salt and bivalent metal ion salts such as magnesium, calcium and zinc salts. The invention further relates to a method for the preparation of the above salts, to a pharmaceutical composition comprising the salts of the invention, to the use of these salts in the treatment of hart disorders or hypertension, in the improvement of gastrointestinal blood flow or in the treatment and prophylaxis of cardiac damages induced by adriamycin and comparable anti-cancer drugs and to crystalline S-a-methylbenzylamine salts of the compounds of formula (I) that are useful as an intermediate in the production of the above mentioned salts.</p> |
