发明名称 |
Tumor suppressor designated TS10q23.3 |
摘要 |
A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
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申请公布号 |
US2003139324(A1) |
申请公布日期 |
2003.07.24 |
申请号 |
US20020299003 |
申请日期 |
2002.11.19 |
申请人 |
STECK PETER;PERSHOUSE MARK A.;JASSER SAMAR A.;YUNG ALFRED W.K.;TAVTIGIAN SEAN V. |
发明人 |
STECK PETER;PERSHOUSE MARK A.;JASSER SAMAR A.;YUNG ALFRED W.K.;TAVTIGIAN SEAN V. |
分类号 |
A61K38/00;A61K48/00;C07K14/47;C12N9/16;C12Q1/68;(IPC1-7):A61K38/17;G01N33/574;C12N9/99;C07H21/04;C12P21/02;C12N5/06 |
主分类号 |
A61K38/00 |
代理机构 |
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