发明名称 |
Antigen presenting system and methods for activation of T-cells |
摘要 |
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8+ T-cells to produce cytokines and become cytotoxic.
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申请公布号 |
US2003138946(A1) |
申请公布日期 |
2003.07.24 |
申请号 |
US20020266463 |
申请日期 |
2002.10.08 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
CAI ZELING;SPRENT JONATHAN;BRUNMARK ANDERS;JACKSON MICHAEL;PETERSON PER A.;LUXEMBOURG ALAIN;LETURCQ DIDIER J.;MORIARTY ANN M. |
分类号 |
C12N15/09;A61K35/14;A61K38/00;A61K48/00;A61P35/00;C07K14/025;C07K14/145;C07K14/705;C07K14/74;C12N5/07;C12N5/0783;C12N5/10;C12N15/12;C12N15/85;C12P21/02;(IPC1-7):C12N5/06;C12N5/08;A61K45/00 |
主分类号 |
C12N15/09 |
代理机构 |
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主权项 |
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地址 |
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