MICROBES HAVING AN ATTENUATING MUTATION COMPRISING A TRANSCRIPTION TERMINATOR
摘要
Compositions comprising a microbe having an attenuating mutation comprising a recombinant transcription terminator insertion in a chromosomal gene are disclosed. The compositions can be used as vaccines or carrier vehicles for delivering a desired protein to an individual. Also disclosed are methods for immunizing an individual and methods of delivering a desired gene product to an individual based upon administration of the compositions.
申请公布号
WO0230457(A9)
申请公布日期
2003.07.24
申请号
WO2001US31606
申请日期
2001.10.11
申请人
WASHINGTON UNIVERSITY IN ST. LOUIS;MEGAN HEALTH, INC.;CURTISS, ROY, III;TINGE, STEVEN, A.