发明名称 Preparation of (r -2-alkyl-3-phenylpropionic acids
摘要 Compounds of formula (I), wherein R1 and R2 are, independently of one another, H, C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxy, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1l-C6alkyloxy, and R3 is C1-C6alkyl, are obtainable in high yields by stereoselective addition of R3-substituted propionic acid esters to R1- and R2-substituted benzaldehydes of formula R-CHO to form corresponding 3-R-3-hydroxy-2-R3-propionic acid esters, conversion of the OH group to a leavaing group, subsequent regioselective elimination to form 3-R-2-R3-propenic acid esters, and their hydrolysis to form corresponding propenic carboxylic acids and their enantioselective hydrogenation, wherein R is (a)
申请公布号 US2003139625(A1) 申请公布日期 2003.07.24
申请号 US20030312855 申请日期 2003.01.02
申请人 STUTZ STEFAN;HEROLD PETER;SPINDLER FELIX;WEISSENSTEINER WALTER;STURM THOMAS 发明人 STUTZ STEFAN;HEROLD PETER;SPINDLER FELIX;WEISSENSTEINER WALTER;STURM THOMAS
分类号 B01J31/24;C07B53/00;C07B61/00;C07C51/36;C07C59/64;C07C59/66;C07C62/34;(IPC1-7):C07C53/134;C07C57/30 主分类号 B01J31/24
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