| 摘要 |
Methods are provided for the selection or screening of an antibody fragment library in bacterial cells by using a Protein Fragment Complementation Assay. The invention also provides nucleic acid molecules that encode fusion proteins, which contain a first part of a reporter molecule (e.g., a DHFR or beta-lactamase fragment), a linker, and an antibody or a functional antibody fragment. The foregoing readily can be adapted for recombinant expression, through the use of vectors and host cells, for example.
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