发明名称 |
Transgenic mammals and reagents for improving long-term memory |
摘要 |
The present invention provides for a transgenic nonhuman mammal whose germ or somatic cells contain a nucleic acid molecule which encodes calcineurin or a variant thereof under the control of a regulatable promoter, introduced into the mammal, or an ancestor thereof, at an embryonic stage. The present invention also provides for a method of evaluating whether a compound is effective in improving long-term memory in a subject suffering from impaired long-term memory which comprises: (a) administering the compound to the transgenic nonhuman mammal of claim 1 wherein the mammal has increased brain-specific calcineurin activity due to expression of the nucleic acid, and (b) comparing the long-term memory of the mammal in step (a) with the long-term memory of the mammal in the absence of the compound so as to determine whether the compound is effective in rescuing the long-term memory defect in the subject.
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申请公布号 |
US2003140360(A1) |
申请公布日期 |
2003.07.24 |
申请号 |
US20030352281 |
申请日期 |
2003.01.27 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
MANSUY ISABELLE M.;WINDER DANNY G.;BACH MARY ELIZABETH;KANDEL ERIC R.;MAYFORD MARK |
分类号 |
A01K67/027;A61K9/12;A61K9/72;A61K45/00;A61P9/04;A61P9/10;A61P21/04;A61P25/00;A61P25/14;A61P25/16;A61P25/24;A61P25/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/16;C12N15/09;G01N33/15;G01N33/50;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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