发明名称 |
Transcriptional co-repressor that interacts with nuclear hormone receptors and uses therefor |
摘要 |
In accordance with the present invention, there are provide novel receptor interacting factors, referred to herein as "SMRT", i.e., a silencing mediator (co-repressor) for retinoic acid receptor (RAR) and thyroid hormone receptor (TR). SMRT is a novel protein whose association with RAR and TR both in solution and on DNA response elements is destabilized by ligand. The interaction of SMRT with mutant receptors correlates with the transcriptional silencing activities of receptors. In vivo, SMRT functions as a potent co-repressor. A GAL4 DNA binding domain (DBD) fusion of SMRT behaves as a frank repressor of a GAL4-dependent reporter. Together, these data identify a novel class of cofactor which is believed to represent an important mediator of hormone action.
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申请公布号 |
US2003138836(A1) |
申请公布日期 |
2003.07.24 |
申请号 |
US20030351750 |
申请日期 |
2003.01.23 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
EVANS RONALD M.;CHEN J. DON |
分类号 |
G01N33/53;A61K39/395;C07K14/47;C07K14/72;C07K16/18;C07K19/00;C12N1/19;C12N5/10;C12N15/09;C12R1/865;C12R1/91;G01N33/15;G01N33/566;G01N33/74;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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