SUBCUTANEOUS ANALYTE SENSOR

摘要

Assembly and method for measuring the concentration of an analyte in a biological matrix. The assembly includes an implantatble optical-sensing element (100) that comprises a body (104), and a membrane (110) mounted on the body in a manner such that the membrane and the body define a cavity. The membrane is permeable to the analyte, but is permeable to background species in the biological matrix. A refractive element (115) is positioned in the cavity. A light source (106) transmits light of a first intensity onto the refractive element, and a light detector (106) receives light of a second intensity that is reflected from the cavity. A controller device optically coupled to the detector compares the first and second light intensities, and relates the intensities to analyte concentration.