PROCESS FOR PREPARING POLYURETHANE-PEO-HEPARIN COATING COMPOSITIONS

摘要

A bio-active coating composition is described which is the reaction product of two different reactions. The first reaction includes reacting a bio-compatible polymer backbone having alpha , beta -unsaturated carbonyl functionality with a hydrophilic spacer having at least one reactive functional group at its first and second ends. In this reaction, one of the reactive functional groups of the spacer reacts with a beta -carbon of the carbonyl functionality to bond the spacer to the polymer backbone. The second reaction includes reacting a bio-active agent with a remaining unreacted reactive functional group of the spacer in the presence of an optional catalyst to covalently bind the bio-active agent to the spacer.