RAPID DETERMINATION OF PROTEIN GLOBAL FOLDS

摘要

This invention provides a method for rapidly obtaining accurate three-dimensional structure of proteins including large or multi-sub unit proteins, using a combination of NMR analysis of backbone only 13C, 15N or 13C and 15N isotopically labeled proteins which are optionally also 2H isotopically labeled in the Calpha position protons and residual dipolar coupling measurements in more than one partially aligned state.