发明名称 |
AN ACYL COENZYME A CARBOXYLASE FROM STREPTOMYCES |
摘要 |
The nucleic acid and amino acid sequences of alpha 1, alpha 2, beta and epsilon subunits of acetyl-CoA carboxylase (ACCase) from Streptomyces coelicolor are provided. This subunit structure differs from that of known acyl carboxylases. Materials and methods are provided of increasing ACCase activity and production of secondary metabolites (such as polyketides and especially antibiotics) by causing expression in <i>Streptomyces</i> of such nucleic acid. Also provided are methods of increasing ACCase activity and production of secondary metabolites (such as polyketides and especially antibiotics) by culturing <i>Streptomyces</i> in the presence of exogenous malonate. |
申请公布号 |
EP1328551(A2) |
申请公布日期 |
2003.07.23 |
申请号 |
EP20010976514 |
申请日期 |
2001.10.23 |
申请人 |
PLANT BIOSCIENCE LIMITED |
发明人 |
GRAMAJO, HUGO CESAR;RODRIGUEZ, EDUARDO, JOSE |
分类号 |
C12N9/00;C12P17/06;C12P17/10 |
主分类号 |
C12N9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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